Collagen 101

Collagen is recognised as the optimal biomaterial for tissue repair as it promotes cellular interaction, migration and regeneration. Collagen is responsible for skin’s strength, texture and elasticity.

Collagen comes from the Greek kolla (glue) and gennao (I produce)

Collagen is the most abundant protein in the body. The Dermis, the inner layer of the skin, is almost entirely made of collagen whose fibres form a supporting mesh or scaffold responsible for skin’s mechanical characteristics such as strength, texture and elasticity. It provides the basic foundation for skin, cushioning and supporting the epidermis (the skin’s surface) and also preventing the epidermis from collapsing in on the muscles and bones underneath.

Collagen production naturally decreases by approximately one percent each year and this loss is accelerated by sun exposure and hormonal changes during the menopause. Without correction, this inevitably contributes to a reduction in the skin’s elasticity, the development of wrinkles and dermal volume loss.

In its purified state, Collagen is mechanically weak and prone to rapid enzymatic degradation. Chemical crosslinking can enhance the mechanical properties and stability of collagen, though cross-linked collagens are less biocompatible due to changes in the overall microstructure and the cytotoxicity of the agents used.

EternoGen’s unique approach shields purified collagen matrices from enzymatic degradation by inhibiting the action of collagenase. The natural open microstructure of collagen is retained forming a highly biocompatible matrix or scaffold for cellular integration and vascularisation to restore the dermal tissue structure and in turn support the skin.